Originally Posted by SCGushue 
I wouldn't be concerned about VPN yet. First, contrary to many opinions, it is in fact largely a result of under-exposure and little else. Not pretty... but can be generally beeliminated with spot on exposure.
As I've noted elsewhere, this makes it hard to take high ISO pictures with several stops of dynamic range, particularly where you need all the sensitivity you can get to get a naturally-light subject correctly exposed and there's even darker areas in the scene.
But again, I only have significant problems (noticeable without pixel-peeping) at ISO 1600 on the K10D -- even 1250 is much improved. If that holds true on the new camera but the practical limit is pushed up to ISO 5000, you sure won't hear me complaining.