Originally Posted by amateur6 
Can anyone else chime in on this? I'm late to this particular party, and my experience so far is NO: there's one adjustment (or maybe 4, depending on what those "AF Area Test" do, but I suspect that they aren't related to different lenses) and it sticks, regardless of the lens (tried DA* 16-50 2.8 and FA 50 1.4).
I'm also wondering -- shouldn't my DA* at f22 (top) be sharper than this, compared to my FA at f4.5 (bottom)? And (tripod and camera did NOT move) what's up with the size difference? Did I get one of the crummy ones? EXIF is intact, if anyone wants to help out with this mystery... THANKS.
Try your DA* at f4.5 as well. At f22 diffraction is occurring. The sweet spot is usually around f5.6 to f8.0.
An example of the effects of diffraction can be seen in this test on Photozone of the D-FA 100 macro.
Pentax SMC-D FA 100mm f/2.8 macro - Review / Test Report
All lenses exhibit this characteristic.