Originally Posted by mr.voigtlander 
Apart from improved image quality with a full frame sensor (or larger format films), the other difference is the bigger the sensor, the shallower the depth of field is at a given f-stop. So this is important for portraiture and when using fast primes for out of focus areas and getting a look. If you shoot Macro however, then maybe this is not a good thing for you.
At a pro level, having that look is all part of standing out from the crowd and making a signature shot.
But don't despair, we have film, you can do it, it ain't nothing new. Old school is good school!
I know you won't agree, but technically and practically the difference in DOF is not that significant.
Actually I don't quite get it yet, but using any of the available DOF calculators online, they tell me the DOF for a given focal lenght, aperture and subject distance is
smaller/shorter in APS-C than for 35mm (?). Anyone care to explain? I thought DOF was shorter for larger formats.