I bought the Pro license which opens up a few options you don't get with the demo nor standard version. VueScan is definitely a bit like the "UNIX" of scanner software in that you really do have to tune it with color film to get good results.
It's absolutely necessary to follow the steps
here if you wish to maintain your sanity scanning color negs. And there are several things that page does not explicitly mention that IMO are critical:
1. Before you begin, select File -> Default Options from the menu to reset everything.
2. "Adjust cropping if necessary" ... It is definitely necessary. Make sure you select "35mm Film" and make sure on that first preview pass you line up the crop box correctly over the scan.
3. If you do not see a completely white strip displayed on that 2nd preview run you
do not have a good color mask and
will not get good colors.
4. Save these settings (and do not touch them in the color tab,
ever) for each film you are scanning so you don't have to do this with every roll. As long as your processing is consistent you should only need to do this once per each film (e.g. Portra 400VC).
During Scanning: With the "Lock Film Base Color" option checked you'll also have the "Lock image color" option available. Use it. Occasionally one or more frames on a strip will not preview with proper color/exposure but others on the same strip will look "correct" when you put the crop box over them. If you lock image color on one of the "correct" frames it will ensure the others on that strip will all be "correct".