I have the purchased it as a photoshop plugin, but it comes as a stand alone as well I'm pretty sure.
You can select 'Load Profiles' while using noise ninja, pretty simple process.
Here's one example. ISO 3200. No other post production, except noise reduction.
1. Entire image, unedited
2. 100% crop of same image
3. Noise Ninja, using my profile
4. 100% crop of the noise reduced image
Note again, that I have not applied sharpening, levels or curves adjustments.