As with with all closeup lens, the effect is to fix your focus distance within a very range - around 3-4 inches, I think. Meaning no matter what lens you mount it to, you'll be focusing at 3-4 inches away. The longer the focal length of the lens, the more magnification you get from a given distance (just like "regular" photography).
I suspect the 250 will vignette pretty badly with the 70-300 - did you research this beforehand to find out this was not the case? For that reaosn as well as for the greater working distance, most people are usually better off with the 150 than the 250. If you find the 250 vignettes, or if you find the working distance too short, you might consider returning that 250 in favor of the 150. Unless you are really sure the extra magnification is worth putting up with those limitations.
I'm moving this to the lens forum, BTW.
Last edited by Marc Sabatella; 07-10-2010 at 06:13 PM.