Originally posted by Adam 77 because the 50-135mm has a pretty useless zoom range. If you want a tele zoom, get a 70-200mm IMO.
I don't understand this comment. On APS-C, I find the 50-135 to be a more useful zoom, as I find that I like being able to use the 50-75mm range more than I would the 135 to 200mm range.
As far as the initial question, a lot depends on what you are shooting. There are plenty of situations where you need the flexibility of shooting with a zoom lens. For instance, taking portraits of kids requires more speed than I can muster to zoom with my feet. On the other hand, the prime will give you faster speed, smaller size, better bokeh.