Originally posted by Adam
This is something that will have to be tested. The 150-450mm is pretty sharp as soon as you stop it down by half a stop, and it also provides the flexibility of a zoom which is a key consideration for a number of applications. However, it's heavy and the ergonomics are quite poor so my guess is that users will likely stick with the 300mm / 60-250mm unless they really need the extra reach, or if they want something for the FF.
For me, there's a dilemma. A long tele prime is ideal with an APS-C sensor because the prime usually outresolve the zoom and the APSC provide the crop factor + ability to crop when having a 24MPixels sensor for instance.
That being said, as we can see the super zooms work pretty well on FF because of the relatively lower resolution requirement and also higher iso capability of the full frame, but then it offers less reach.
The choice of the long zoom over the prime is closely related to the shooting conditions. For birding, focal length is never long enough, cropping often done, except that with proper hiding approach, a long lens is not required anymore but the flexibility of the zoom is then more valuable thanks to proper framing, and in the same situation a 300mm prime is also suitable. For larger animals or sports, the targets are larger, so that no heavy cropping is needed, in this case, the flexibility of a zoom is also an advantage.
Now, according to a pro safari photographer (Nikon user), the most used lens (>80% of shots) is the Nikon 200-400 f4 + APSC camera/or +TC on FF. The DFA 150-450 covers a bit more than this range.
But, IMO, the DFA 150-450 is not really for birding. However , for a safari in Africa, the DFA 150-450 seems to be the right lens.