Originally posted by Lee Malta
So if I just put the lens on its own I guess I have to set the Focal length to 75 mm
No, just set the focal length to 50mm.
The crop factor is only important for comparison of field of view on different sensor sizes but must not be used for the shake reduction system (Otherwise you would overcompensate and might get more blur than without SR)
As for the extension tubes I usually type in the focal length of the used lens for the correct exif information and deactivate SR.
Yes, the higher your magnification gets (or the closer you get) the more influence has camera movement on the sharpness of the image and you could compensate for that by increasing the focal length for SR but as I said before when you set the wrong focal length you might end up with even more blur. So I either use a tripod for macro work (SR off anyway) or when photographing insects I use a higher shutter speed to decrease the effect of camera movement (this also helps freezing insect movement)