It's nothing to worry about if you're careful
First, use a bulb blower to get rid of any dust. Then, use a clean, small, soft-bristled brush (I use very soft make-up brushes) to gently remove any remaining dust and or debris, and give it a final blast with the bulb blower, just to be sure. Then, moisten a single-use lens paper tissue or other single-use optical wipe with a couple of drops of isopropyl alcohol. Alternatively (and my preference) use a pre-packaged, pre-moistened optical wipe. I like Zeiss wipes, but they're pretty wet straight out of the packet, so I let some of the alcohol evaporate off such that it's damp but no longer wet. Wipe the rear element gently, and in a circular motion starting from the centre to the outer edge.
Unless you've abrasive debris on the rear element, or the wipe you use is contaminated from previous use (which is why I recommend single use lens tissues or wipes), it's extremely unlikely that you'll mark the glass or coatings. Even the rear elements on these modern lenses are remarkably resistant to scratching.