Two (oh well, make it three) gripes I have with the 55-300 PLM:
1) 6.3 aperture from about 280mm means you lose light and have to compromise with shutter speed and ISO
2) 6.3 aperture from about 280mm means focus will HUNT a lot and slowly which can make you miss shots. There's an easy solution for that one though: turn the focal length back to where it's still at an aperture of 5.6, acquire focus, then zoom in for the rest if necessary.
3) It's not ultimately sharp (but still plenty sharp!) wide open at 300mm. Stopping down helps with that, but that means you'll lose some light again. Perhaps the need to compromise with shutter speed and ISO also contributes to my practical experiences that images could be 5% sharper? But in the end, I don't think that matters.
All of those don't matter because:
1) The zoom range and focus speed make it sooo versatile. I couldn't have gotten a shot like this with the DA* 300:
Common Kestrel + Prey 2
2) It's so small and light. You can take it with you whenever you take your camera, and you won't regret it. The DA* 300 can get heavy after some time... sometimes my hand hurts from holding it up for so long. But if you need every bit of light, f/4 helps, and it's sharp as a razor from f/4. And that aperture also enables you to use a tele converter if you need the reach. You can also use a tele converter with the 55-300 PLM,
but you need a lot of light. The only problem
I have with using a teleconverter with the DA* 300: there are no correction profiles for the combinations for DxO PhotoLab which I use to convert my images. Which leads me to another point...
3) There
are correction profiles for the 55-300 PLM, including lens sharpness which gets you very close to ultimate sharpness.