Originally posted by ColColt As I mentioned, I believe the curl or lack of flatness seems to be a major problem area. A negative carrier will pretty much flatten(being of metal) any negative and I always used a grain magnifier to get the best from a given negative. I can't use that with a scanner...wish I could. I've never read anything about being able to adjust the focus on either of the scanners I have. Even if you could, there's no "live view" to see what you're doing.
I use a Minolta Dimage II for my slide and negative scans. It is limited to 35mm so it may not be of help, but it does have a focus adjustment built in, which helps in the event that the frame is not 100% flat
My biggest issue with curl is when I have a single negative frame, usually because it is at the end of a strip. The Minolta carrier has clamping bars that pinch the negative strip between frames as well as the ends of the strip, so the strip collectively has 7 clamps that press the strip flat. But a single frame is not always cut with excess to really press it flat so it tends to bow in the centre
Slides are not an issue because they are mounted, and that seems,mover time to result in good flat frames. I scanned all 20,000 of my film shots with this scanner and never had focus and sharpness issues with the scans, you could at 2880dpi see the grain quite well,