I vote for the DA* 16-50 as the #1 vacation lens choice.
My 16-50 took a quick road trip through the West when we decided to
drive back home from California rather than fly.
I highly recommend the drive through Nevada, Utah, and Colorado on the
way to the midwest or East from California. Everyone should find the time for
that road trip at least once in their lives. The American West is truly beautiful.
Here are some shots taken by the 16-50 during the trip - These were taken
in Utah (Zion area) & Colorado (Rockies - Vail, etc.) (All the snowy Rockies
shots were taken from an open passenger window while my wife drove!)
Infinity focus is exceptional, and the lens's resolution really shines here.
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That last shot shows our rental - I took a quick hike up an outcrop to get the
valley. The wind was around 40mph up there.
.