After using it since the developer preview, and installing it on my daughters laptop (she's 10), I really can't comprehend the issues. The desktop is still there. All the standard windows functions are there, albeit moved around in some cases, but pretty much every new version of windows has had this issue. Any software, hardware, and use cases I have thrown at 8 has worked just fine. I am getting accustomed to the modern UI or whatever they call it (I'll still use metro), as everything I need to know about is live and updated in one screen.
The other thing I like is that the main screen is useful, rather than a dumping ground for apps, shortcuts and files that no one knows what they are. I do computer service on the side and 80% of the systems I fix have their desktop FILLED with links that don't work, files they don't understand, shortcuts to multiple versions of software that don't exist OR files they do need that get deleted because people don't know how to save files, or where to save them. A simplification of the user interface is LONG overdue. People keep saying they are upset that the desktop is gone. I say GOOD RIDDANCE! Its long overdue, along with getting rid of over 20 YEARS of legacy support that does nothing but slow down the system and make it harder to implement a modern, secure architecture.
As far as businesses are concerned, I would think it would be a welcome addition, as instead of teaching people how to navigate multiple levels of menus to find an application, its right on the desktop, right in front of them. Implement a tile for the apps that the users are to use, and lock down everything else.
Let the arrows begin to fly...