Road: Orbea Orca w/DA 10 speed, Titec Ithys Patron saddle.
MTB: Trek 8500 SL with Deore/Deore XT and Titec Berserker saddle
CX: Redline another Titec saddle, just can't remember....
To clarify: the issue is the correct position of the ischial tuberosity bones sitting correctly on the saddle - they should be near the edge or along the edge of the top of the saddle. Confirm that you don't have swelling in the perineal area near those bones - that may indicate another issue.
Make sure you have the bike on a level surface, and use an actual level that rests on the length of the saddle. It should be approx. level. As Robert indicated, the tip being too high WILL cause numbness, and too low will cause shoulder/neck pain, because you're fighting the effect of sliding forward.
Do you use padded shorts of some kind?
Regards,
Marc