Originally posted by slomojoe You can actually make libraries of random peptides or RNA oligomers and reproducibly isolate some that not only reliably assume certain folds, but also display specific biochemical functions.
That is true, but they were built around existing templates. Could we categories this to a designer molecule? My knowledge is limited, is there any molecules made to work without templates?
Originally posted by slomojoe Folding is an intrinsic property of polypeptide chains, and if there is one thing that evolution can explain well is the ability of proteins to reliably fold, because they are continuously selected to do precisely that.
I agree to that to an extent but not entirely. Mutation is when proteins fold better or miss-fold to generate stronger or more selective off-springs.
Originally posted by slomojoe There really is a huge literature on both the physical chemistry of protein folding and the evolution thereof. It's really no big mystery.
To my understanding, protein folding is still an unsolved scientific problem. There are only two existing methods to “photography”/ calculates accurate 3D structure. Everything else (
in silico) are predictions.
Originally posted by falconeye Luciferase, I apologize for having offended you. What I certainly did.
No, I didn’t think you offended me. As I see from your earlier post, you’re intellect and kind. I admire your knowledge and experience. Just sometimes, “Letters are men’s most addictive drug, and the source of misunderstanding.” Quote taken from somewhere.
Originally posted by falconeye I was involved in the early phase of development of a formalism which is now called "Energy Landscape"
Energy landscape - Wikipedia, the free encyclopedia. In my PhD thesis I used this formalism to better understand the emergence of complex structures in solid state physics.
I sincerely respect and thank you for all that you have done and will do to contribute to our knowledge.
Although I do not have a physical chemistry background, but I will read about energy landscape until I can grasp your point. Thank you for your input.