Can you upload some sample photos to get a better idea of what the problem is?
The very narrow aperture is definitely part of the problem as already suggested as is possible autofocus calibration being needed.
Since you use it predominantly at maximum focal length do the calibration also at max focal length and use a subject that is at a distance similar to what you most often shoot rather than using a nearby calibration chart. I find easiest way to calibrate is focus and shoot in live view, switch to OVF, half press again the shutter while carefully observing how the focus moves. Adjust the AF calibration and repeat until you get to the point when there is least movement (or none at all) between live view and OVF.
Additionally, if you are using shake reduction:
1. Allow for the shake reduction to stabilise - once you are steady half press the shutter, wait for the hand icon to be steadily lit and only then press full. If you realease the shutter before that the SR might make the picture more blurry instead of sharper.
2. If the lens has its own stabilisation (as various Sigma do) make sure that you do not switch on both the stabilisation in the lens as well as the in-body SR of the camera. Use either the in camera SR or the stabilisation in the lens but never both at the same time.
If you are not using shake reduction then try it out. I find it very effective and have been able to shoot at 500mm at 1/150 second (with some luck even 1/50), four or five times slower than the rule of thumb.
Last edited by lister6520; 09-30-2013 at 11:06 AM.
Reason: Corrected incomprehensible sentence