I was just scanning through DPR's preview of the 5D Mark II and I was a bit surprised. The IQ is of course incredible through ISO3200 (it better be for $3000), but if their series of high ISO pics at the end of this gallery is accurate I wouldn't use anything over ISO3200. ISO6400 starts to show horizontal banding and the problem just gets out of control over that.
Canon EOS 5D Mark II Beta Preview Gallery Gallery: Digital Photography Review
Seeing as how the $1500 Canon 50D is fine through ISO1600 all you get for twice the money is:
- A slightly larger viewfinder
- 1 extra high ISO stop
- Slightly better DOF control
- 850 more horizontal pixels (more on this below)
For me personally that is an easy call. I know some people want the purity of FF, and that's fine, but at what cost? If prices were a bit closer between the two I could see someone make a case for it. But as it is now you have to really really really want FF to pay twice the money for those minor advantages (plus the 50D shoots faster and has a built in flash).
Now as far as the printing extremely large argument goes...as I noted in my final bullet point, the 5D is only producing images 850 pixels wider than the 50D. If you say that you can tell a difference in that resolution difference at even a very large print like 20x30 then you are lying.
50D = 4752 x 3168: 158dpi at 20x30"
5D = 5616 x 3744. That is 187dpi at 20x30"
So at very large sizes we are talking about a difference in 29dpi. Now the only way to tell a difference in that is to pull out a loop...and even that might not help. Besides, if you are that anal over the slight differences you're not looking at the big picture (pun intended).
So if wall murals are your ultimate goal then going 21 megapixel FF really isn't going to help you all that much. Once again, the answer is medium format. Just like it has always been.