I fly professionally, all the time.
I check photo gear, all the time.
I have a shoot in Chicago Monday, the UK the following week, as an example, I'm not hypothetical in my opinion.
Direct flights are your friend, as there is less "handling" of your baggage.
Cheaper multiple stops can be the death of your gear.
I use my two carry on pieces to carry the most expensive gear and my fail safe gear.
I do not rely on Pelican or hard cases for most of my gear - my drone and slider cases, and my lighting cases being the exception.
Why?
As soon as TSA goes through those hard cases, often, they do not know how to close the non-standard clasps that are different across hard case manufacturers.
Believe it or not, the time it takes to close some of the clasps seems to be too much trouble for many security folks.
I use TSA cable locks as an additional step to try and assure things get put back together.
I am NEVER 100% sure my hard cases are going to come out alive - even though they are "tougher" than the soft cases I use.
I hate to say it, but the TSA and security folks understand how zippers work, and all of my Think Tank Logistic managers are always closed on arrival.
From a practical flying perspective, in my opinion, Think Tank cases, because they are "soft" and are like luggage, tend to go through the system better than hard cases which have their own size and shape and are often a target for mishandling.
When a Pelican case goes by, people instinctively want to see "What is so expensive that it has to be in one of those".
Photo gear that looks like luggage, is under the radar and is as protected.
https://www.thinktankphoto.com/ https://www.thinktankphoto.com/pages/rolling-cases https://www.thinktankphoto.com/collections/manager-series/products/logistics-manager-30