I'll give another "thumbs-up" for Domke bags. I have a Domke F-3x that is my walking around bag. I was carrying it at a recent field trip with my camera club and one of the other long-time members laughed at my Domke and said, "How long have you had that bag?" I honestly couldn't remember. I think I bought it shortly after Domke released the F-3x, though, because I had been eyeing the F-2, but thought it was a bit too big. Let's just say it was a LONG time ago!
I have no idea when...or if...the thing will ever wear out. Except for losing a small bit of the rubber in the shoulder strap, it looks pretty much the way it did when I bought it all those years ago. I didn't list it as my perfect camera bag, but it's certainly my most used bag. I work out of my car a lot, so my normal routine when I'm going on a shoot is to take a large LowePro with enough gear to handle any situation. Then, once I'm on-site and see what's happening, I'll choose a more specific set of gear, toss it in the Domke, and head out.