Although I think this thread is directed towards K-1 users, I thought I'd mention my experience as well, because I think the
post-processing stage is critical
I shoot with a K-3 II and post-process my images in RawTherapee, which features several robust noise-reduction approaches. Depending on whether I plan to print an image, I'm comfortable going as high as ISO 3200, maybe ISO 6400 in a pinch. For 'large' prints such as 20x30 inches, I would limit it to ISO 800. From what I understand of the K-1, if I owned it I think I'd be comfortable going a stop higher, say ISO 6400.
More discussion on this topic may be found in a recent thread:
Iso .. how high is too high for you? - PentaxForums.com
- Craig