I have already dug into this topic, and even opened a dedicated thread on DxO support forums. Other users weighed in, but so far I've seen no improvement in DeepPrime XD for KIII mk3, which is unfortunate. Lately I have downloaded a few samples from the usual DPreview studio set, from various cameras and my conclusions are as presented in the thread (where perhaps I mentioned no raw files being available in DPreview database for K3iii, but they are available now). For almost any camera DPXD is essentially black magic. Fuji 26mpix and even the new 40mpix sensors in particular are incredible (XD support for Xtrans was added in a recent update). I have tried full frame big mpix cameras, micro 4/3 cameras...always XD yields great results out of the box, better than DP. With the K-3iii even standard deepprime has "subpar" performance, but XD is totally broken. It always degrades image quality by introducing artifacts and actually increasing noise in out of focus/uniform areas. Completely opposite behavior with respect to other cameras.
This is an indirect result of Pentax's questionable choice of applying a level of in-camera noise reduction baked into the raw that is significantly stronger than any other camera on the market. Pentax cameras with accelerator chips are an outlier in the training dataset. The statistical properties of the noise are unlike any other camera. Therefore to adapt the model to this specific type of file would require a level of fine tuning that is probably not considered worth the effort by DxO. As a matter of fact, DP and XD work worse on the K1ii than on the K1, see for yourself on DPr samples. I have to say that the KP behaves pretty well in spite of the accelerator. So there is hope that they could fix it sooner or later.
Luckily the problem is worse at very high ISO, where it is unlikely that image quality is critical. Up to ISO4000-5000 deep prime (non XD) does a decent job on the K-3iii. Yes it works much better on other cameras with (essentially) the same sensor like the Fujis. But up to that sensitivity the difference is at the level of "pixel peeping". At 12800 ISO performance is really poor in comparison to other cameras.
Possible problem in DeepPrime XD support for Pentax K-3iii - DxO PhotoLab - DxO Forums
Advanced AI denoise like DxO (I am not a fan of Topaz), fully integrated in a powerful raw processor, is really a game changer. For most cameras (unfortunately not the K-3iii...) it is set and forget, just leave DPXD always enabled at default settings and it does the trick. Artifacts are very rare and occur if you push it too much (which is not needed). Almost every camera, including M4/3 sensors, becomes usable up to ISO12800, or more. The amount of detail that it is able to salvage is staggering. Among the samples I have tried I particularly like the output of "high density" sensors like the new fuji 40MP, clean yet natural; and the advantage with respect to "standard" denoise algorithms is clear as day for those sensors.