I bought my father-in-law a Fastpack 350 for Christmas. After Christmas I had to pack my gear into it and take it on the plane to deliver it to him as he couldnt carry it and other presents home.
The 350 has heaps of storage and great padding protection but I thought it a bit heavy (over 4lbs) and it felt a little "boxy". I'm 5'10 and 155lbs
It's Fine if you are reasonbly big framed guy but I might guess you be quite the opposite.
I currently have my eye on a Kata DR467i
Kata KT DR-467I-BB Digital Rucksack (Black) KT DR-467I-BB B&H
Its cheaper and 1 lb lighter and can fit a Kata designed trolley if you want the wheels (as an option)
If you dont like the black they (used to) make it in other lighter colours, light white/tan, white/yellow etc and there may be stock left over.
The only thing it says that it suits a 15.4" laptop but one of the reviews says they can easily fit a 17" Macbook.
Another which I can think of is a Tamrac Aero 80 or 85. They can surely take a 17". I did look at one of these and I found the (new) zippers a bit tight although this makes them more waterproof.
Anyway, with pretty much any backpack I'd would want to check it out with gear first.
Good luck.