Hi JP,
I agree with stormtech and jatrax in this, at least for the Sigma 500/4.5. It's a relatively light lens compared to other big glass, just a little heavier than the average 300/2.8, and not incredibly long, so the supplied tripod collar should be easily enough to give you adequate support. You'll probably want a long plate (I use Arca Swiss compatible clamps and plates) so you can balance the camera/lens on the head though. I suggest looking at rainbowimaging, oecamera, and krosno65 on ebay as sources for all kinds of good Arca compatible stuff at reasonable prices. Krosno65, in particular makes custom plates to spec if you want a thick plate for extra stiffness, and has a lens support system, though I can't for the life of me figure out exactly how it works.
As far as how long a plate you'll need to balance this setup, I really don't know, but the Acratech site has a "plate finder" page, and they say about 154mm (6") for the 500/4.5. This sounds a bit long to me as I don't need anything longer than about 100mm for my 300/2.8s, but too long is better than too short, and the longer plates are easier to use as handles to carry the camera/lens or lens alone when not attached to the tripod. One cool tip about most big Sigma glass is that they all seem to use the same tripod collars, and only have two variations, with either a long or short foot (the short foot seems to be std).
Rainbowimaging has a Kiwiphoto 169mm plate for $26.99. Compare this to $79 for an Arca Swiss 150mm or $65 for an RRS 152mm, or Acratech for a 6" plate. . .
Manfrotto also makes a lens support plate, Mod 293, but I think something like this is not really needed for this class of lens.
Manfrotto 293 Telephoto Lens Support with Quick Release 293 B&H
As stormtech suggests, you're really mounting the camera on the lens, not the other way around. If you're worried about the mount on either the lens or the camera, I've spent many, many full days carrying various Pentax bodies with a 6 lb + lens mounted -- I carry it in my hand with a grip strap, not with a neck strap, so the weight of the lens is borne on the mount, and normally carry at least a 2 lb lens mounted on my cameras -- and I've never had the slightest bit of wear, warping, or loosening on either mount
Scott