I've had 2 LowePro Novas - I think a 30 and a 50. I thought they were too square and uncomfortable. After a thoughtful assessment of real usage I'm down to 4 bags:
- Domke F2 - canvas, holds 2 film bodies and up to 10 lenses
- Domke F3 - canvas, holds 1 dSLR with 28~105, 3 normal/wides & AF540FGZ & Batteries
- Domke F5 - canvas, holds Q-7, 4 lenses, a tiny tripod and accessories
- LowePro 200 AW Backpack - holds dSLR, 70~200 Zoom or 300 Prime, 8-10 lenses, AF540 flash, junk and a full tripod
I like the unstructured form of the Domke bags. I have a postman shoulder strap for the F-2 and gripper straps and hand straps for the others.
Almost every time I go out I take the F3 with the K-1 and lenses (before K-1 that was K-3 and DA Limiteds, and it is a bit tight now). If I'm going on a longer vacation I usually take that set up plus a long lens in a sleeve in another place. Light vacation is the Q7 kit.
The backpack or F2 I fill with lenses and go out to play for the afternoon or day, but both are really just for 'Car Camping', not traveling. I can also take one film camera, a few lenses, a flash and film in the F-3 very comfortably.
I would consider the Domke F3 bag in one of its various fabrics.