Hello rawr,
DeNoise is pretty straight forward to use. Not that complicated at all, however, to make the most of the program, follow the directions exactly as shown. If you use DXO Optics Pro like I do, zero out and turn off
all the settings except the lens modules (I made a preset for that), then, the first thing you will do when you open the TIFF in Photoshop is to go straight to the DeNoise plugin and run it. I like to use it manually, but it is also possible to make presets for each ISO setting for your camera as a starting point.
Here is a link to a YouTube video webinar given by Nichole, demonstrating the complete workflow of DeNoise 5:
The tutorials on the web site by Dr. Yang are also very good.
I also spoke with Nichole on the phone regarding workflow and she is very knowledgeable and a great person. She is a photographer herself, so she is in a very good grasp of the product and its capabilities.
Also, there is a 30 day free trial that is fully functional, so there is nothing to lose here.
I look forward to your thoughts,
Don