Originally posted by Rayn and that seemed to fix the issue, but it's back now..
The Nvidia driverGUI on X server generates a file "xorg.conf"
I presume something similar on Win.
After a change is done on the Nvidia GUI, it is necessary to press "Save to X config file", otherwise it can revert to the settings in that file.
Also if your Nvidia driver is not the latest version fully supporting your GPU, the GUI might not be able to fully complete the "xorg.conf"
( I recall having to to edit that file manually to get Truecolor working persistently on the Quadro)
Drivers | GeForce https://forums.geforce.com/