It can be counterproductive, trying to comply with some orthodox principle like Rule of Thirds by aggressively cropping to an unorthodox aspect ratio.
Best to get that right in camera.
Something in a weird aspect ratio draws attention to itself, as if it's a product of the shooter's mistake.
I don't mean a panorama, or an edge composition or something where the artistic intent is clear, but the ones that scream out "I took the shot too late, there's an awkward person at the bottom left, I'll just crop them out."