I'm a bit surprised that more of us aren't talking about or recommending backups "in the cloud" as part of a backup workflow Ben mentioned it in his post, but gave it short shrift as not being a very viable technology. I disagree and think it should be part of all of our strategy.
I have recently begun using
Mozy as my cloud backup solution and although I could handle a complicated backup program, it's dead simple to use. In fact, it's currently churning away at backing up all my data--slowly. Other solutions like
Backblaze,
Carbonite,
SugarSync,
JungleDisk, and
Amazon S3 services are also perfect for this. Amazon S3 is probably the best solution for the paranoid (I use that term affectionately, not demeaningly). Of course, they aren't perfect, but none of the other solutions are, either. The biggest issues are slow initial uploads (especially for hundreds of gigabytes), delay in restoring your data as it downloads, recurring monthly fee--although Mozy and Backblaze are only $5 a month for unlimited storage--and theoretical privacy issues.
Obviously, we could all be diligent about backups, but it seems to me that unless we are masterful artists who should feel a duty to preserve their work for future society's benefit, then it is more than sufficient to have a primary storage drive, external drive backup (perhaps coupled with offsite removable media backups if you're really worried about needing fast access to data in the case of a catastrophic failure or damage of your system) and a backup in the cloud through one of the various vendors (or roll your own with an offsite computer). And it you aren't worried about needing immediate (or rapid) access to ALL of your files, then you could skip the secondary drive and just use the cloud backup for $5 or less a month.
Personally, I'll feel better when I implement another external drive to backup everything on location (merely in the event of drive failure), but not everyone needs elaborate backup schemes. In fact I think practically none of us do and we'd get more people to backup if the vocal advocates didn't make it appear so darn complicated.