Since there havnt been too many direct answers to the OP, I'll chime in:
I virtually never use the concept directly. I'm too much of a pixel peeper to accept the relatively low degree of sharpness that exists throughout much of the "zone of allegedly acceptable sharpness" as predicted by DOF / hyperfocal calculations. I'd usually rather designate one "focal point" in the image to be maximally sharp and focus there directly, even if this means my DOF as measured by a DOF calculation isn't maximally deep. I do this despite knowing full well I'm often being too picky about sharpness for my own good. Although I would say that some of this feeling also comes from my experience as a landscape *painter*, where I generally take the same approach. In fact, we usually rely on deliberately making the far distance background a little softer (and cooler, and less saturated, and lower contrast) to help create the illusion of depth.
Last edited by Marc Sabatella; 07-05-2010 at 09:44 AM.