Shutter failure & repair with the 645D has been discussed in previous threads, just search the forum. I'm one who had my 645D shutter fail right around 50K, but I avoided the repair cost because it was still under warranty. I shoot a fair amount of frames compared to most medium format users, and I work in a pretty strong range of outdoor conditions from cold to wet to hot to dusty. Medium format cameras are usually designed with a very different shooting and usage profile compared to 35mm gear, typically intended for low volume work.
I can't say a 50K actuation shutter rating is standard for other MF vendors but it doesn't seem unreasonable to me, even though mine actually did fail. $1000 repair cost is probably cheap compared to other MF cameras that cost much more than the 645D. The mirror & shutter assembly is the primary mechanical component in the camera and this is a very low-volume, niche market product therefore relatively higher cost of parts and labour.
Extended ISO goes to 1600, as noted above. It is grainy but usable depending on the circumstances and image use.
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