Well, it had to happen I guess - I went to Cappadocia for a 4-day shooting, and after coming back home and starting to work on the photographs I found a very nice looking, very bright red line in any image taken after exposure _6450275: since my first image of the trip is _6450263, basically all the 300 images I shot over there got it. Once I got home and I found out, I immediately run a pixel mapping which thankfully solved the problem the first time over. This things happen of course, and I am glad Pentax included a pixel-mapping feature in the 645D which immediately fixed the issue for me. I wasn't expecting it to happen so soon though, which is why I wasn't checking pictures at 100% in the field - sadly so, if I did check now I'd have many less ruined pictures. Oh well, lesson learned: now, all I have to do is fix the red line in the ~60 keepers from the trip...
So I guess the point of this story is, no matter how new your camera is, keep checking for dead pixels - they can creep in when you less expect them!