Hi, I use it with the 645D. In general, the software is a bit slower than Capture One. I don't know about LR. May computer is a Mid 2011 27" iMac with the cheapest CPU.
One thing I noticed quite quickly: If you have a folder with dozends of photos and scroll back and forward between them to thow away the bad ones, work on the good one and so on, the amount of memory required goes up quite quickly. The original 4 GB was not enough for the Nikon D2x I owned before I baught the 645D. For the quite small files of the D2x upgrade to 12 GB was fine. For the 645D it was tight agani, I did another upgrade to 24 GB - athough this Mac officially only supports 4 GB DIMMs, you can run 8 GB ones, too, as it t common intel hardware supporting 8 GB SO DIMMS.
If you thinking to use Pocus with the even bigger 50 MP files, 16 GB memory is a bre minimun you will have to restart the software after browing 30 to 50 photos in RAW. Better go for 32 GB, then it will work fine.
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