These lenses are different and have different purposes. A direct comparison might be difficult.
The 18-250mm is an all-around lens, that is well-regarded among all brand.
The 18-250mm is however a different lens from the 50-300mm. The main point with the 55-300mm is the need for another lens to cover the same wide range, hence of lens swapping. Otherwise it is well liked by many Pentaxians with excellent user reviews in this forum.
The latest DXOMarks (lab results from DXO) gave the following overall scores for the all-around lenses:
DA18-250mm = 10
Canon 18-200mm IS = 6
Niikon 18-200mm VR = 7
Sigma 18-250mm HSM OS = 8
Pentax 50-300mm = 5
Pentax 50-200mm = 4
These results must be considered with care since they are somehow surprising for the 50-300mm. (I am sure that some DA50-300mm owner will jump at the score...)
Hope that the comment will help....