Screen calibration cannot be set by using the working colour space environments in Lightroom, CS6 or other editing software.
Screen calibration should be ideally treated as part of a total colour management work flow i.e. at all three stages, image capture, screen viewing and finally printing. This is critical if your working with images where the colours need to be accurate. Normally you will need to get a bit hardware and software from the likes of X-Rite, their Colour Munki Dislay or the one I now recommend, i1 Display Pro, Google them for more info.
At the time of the shoot, I use the X-Rite colour checker passport. From which I can set the white balance correctly "in camera". Whilst I shoot in RAW DNG, viewing the images on the back of the camera, are as we all know jpeg, so it helps if the white balance is accurate, especially if you need to show others at the time of the shoot, what a great job your doing.
The colour checker passport software also creates a unique camera profile for those specific shooting lighting conditions, which when loaded into Lightroom, ACR and CS6, ensures the colours are correct for that shoot. My screen is also calibrated with the i1 Display Pro (or it will be shortly when it arrives, I'm just about to switch over from another system). Printing I'm not too worried about because I send out my work to a print house, so they get colour correct files from me, they are colour managed too, so the prints come back perfect.
It sounds like a huge hassle, really it's not, it saves so much time in PP to get perfect colour results, once done it's a just a couple of mouse clicks.
Now just briefly, working colour space environments, I work and edit in ProPhoto in both Lightroom & CS6 to give me the best possible on screen image to the limit of what my monitor is capable of doing. Export or saving to images for the web should be done as sRGB, otherwise all sorts of strange things happen.
Please bear in mind this is just my work flow, I'm sure there are other ways that could be equally as good, but this is what works for me, hope it helps.
Last edited by Kerrowdown; 04-21-2013 at 01:26 PM.