Originally posted by Digitalis
Higher resolution sensor will resolve more and thus the effects of diffraction to be visible earlier: 24Mp full frame Vs 16Mp APS-C. There are also the aforementioned issues in the posts above to consider as well.
This is it......^ (plus 1)
The better the lens, the wider the sharpest aperture.
Look at the FA 31 ltd.
Pentax SMC FA 31mm f/1.8 AL Limited - Lab Test / Review - Analysis
Being a generally excellent lens, it's sharpest at ƒ2.8.
The SMC 35 2.4 on the other hand is sharpest at ƒ4
The DA 21 ltd. is sharpest at ƒ5.6.
So if you see where I'm going, as the quality of the optics goes down, the sharpest ƒ-stop is higher. With lenses 300mm and over you also run into lenses that are sharpest at ƒ8. SO there are a number of factors, the quality of the optics, and focal length probably being the big 2.
Personally, I wouldn't spend too much time on this. Test the lenses you have, utilize your test results. Apart from what I've contributed, which only shows you what to expect, you have to evaluate your own lenses individually. Sample variation is enough to over-ride assumptions made from single lens measurements done in a lab.
For example, I've noticed the DA 21 ltd. is very good for pastoral almost pastel images. It's not the sharpest, but it renders nicely especially in low contrast transitions. (Where as I'm guessing the DFA 21 2.4 probably renders well for pretty much everything.) The DA 21 is not good for contrasty sunsets. You figure out what a cheaper lens is good for, then use it to its strength. This is more important for cheaper lenses. They are almost all good for something, you just have to figure out what.