There's a good Epson Printer forum hosted by Yahoo! Groups. Many friendly and helpful folks there:
EPSON_Printers : EPSON Printers (World's Largest)
Getting all the color management settings optimized is quite bizantine.
Color management setup will vary depending on your O/S (XP, Vista, 7?, Mac), application and printer driver. For complete color management, you will need to adjust settings in all 3, (at least on Windows platforms)
Ian Lyons has documented the settings in detail for printing in Photoshop to Epson printers. He's covered many generations of printers, PS and O/S. You may have to read a few different articles, but I've followed Ian's instructions for many years.
Computer Darkroom - Home
If you are on Windows, you should look into Qimage from DDIsoft. It's a low cost but very sophisticated printing application with built in color management, state of the art image scaling/interpolation and print sharpening. I've used it for many years, and the upgrades have been free. DDIsoft has a forum where you can get lots of help.
Qimage Professional Quality Photo Printing Software
Hope this helps