My two cents...
Yes... there is an IQ difference between Larger sensors to smaller sensors. Its been discussed many times all over various photo-related forums. There are so many factors here... from density of the photo-sites to signal to noise rations to loss of dynamic range. Do not forget that the sensor itself is not the only factor that translates to IQ
Yes... CoC is indirectly related to the sensor size. The formula includes a variable for viewing distance which is in turn related to focal length and enlargement. Both of which are impacted by the size of the sensor. Several references for CoC online report a different value depending on the size of the sensor. CoC can be directly related to DOF.
No.. IMO, DOF is not a factor of image quality. Its simply a characteristic of shooting with some specific format. If you shoot subject matter photos (portraits), then how DOF is rendered is an important aspect of the tools chosen to create said photo. If you shoot story telling photos (journalists), then a deeper DOF may be an even more important aspect of the tools chosen. This is just as incorrect as a shooter with a preference towards the "look" of wide angles claiming that IQ of shorter focal lengths is better than longer focal lengths.
Yes... Crop sensors simple crop (in turn enlarge) the middle image circle of a lens. IMO, this places a higher demand on the optics. Enlargement also means a magnification of the inherent flaws of the current lens.
I think this statement is important enough to quote:
Originally posted by Rondec The question often isn't one of whether full frame has better image quality, but whether or not APS-C is adequate for one's needs. Many of the people on the forum are hobbyists for whom the cost of full frame would not provide significant benefits in their every day shooting.
The Micro 4/3rds group (2x crop sensors) is highly aware over the disadvantages inherent with choosing a camera with a smaller sensor over DSLRs. A large portion of this group also owns various other pieces of equipment ranging from digital MF to FF (me included). But they are also highly aware of the advantages the Micro 4/3rds system offers.. its more than adequate for their needs in certain situations. Rarely you'll see someone posting that the crop sensor outperforms FF in certain aspects of IQ BUT they still head out the door with the M43 camera in pocket .... quite often.