At high ISOs the 2s just doesn't stand a chance against FF. Comparing again with the D4 (arguably the best FF in noise level at high ISO), at 6400 the 2s loses by at least a stop. Against the D600 it is a bit better, but just a bit.
Against the X-Pro it's more complicated as my software don't support the X-CMOS sensor so I have to compare the 2s DNG against Xpro in camera JPG at 6400:
X-Pro1 (in-camera JPG NR1, whatever that is)
K5-IIs (from DNG, no PP)
The X-pro is a bit over exposed (1/500 vs 1/800). From these, I think noise performance is about the same-the 2s' can be NR'd to the same noise level *and* detail as the Xpro jpg-but the 2s is a bit sharper looking at the Samuel Smith Label, and it also seems to use better lens! If we look at the proportional scale the instructions are more readable on the 2s, so the edge sharpness is better on the 2s. At first I thought it's the NR, but looking at the ISO 100 shot it is the same (assuming NR is less severe at that ISO), the 2s is sharper there.
Just my observations on a boring friday night,
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edit: Actually they are using very different FLs. 2s using 70mm, Xpro using a 35mm. So disregard the comment on sharpness please :P