Originally posted by Mikesul You may also find the weight with any lens easier to handle if you have a good strap like the Peak Design and some others. That way you only feel the weight of the camera when you pick it up to shoot. Even the really big lenses like the 70-200 and even the 150-450 are not too bad to carry with an appropriate strap.
For my use, the weight of the gear is more than that. I'm usually carrying 50 pounds of other equipment and 10 pounds of camera gear sometimes for a mile or more. Or if you are a back packer your whole world is on your back. There are many situations for out doors types where those lenses are too heavy and will end up causing a lot of pain physically were you to take them. After a few kms hiking, the weight does get to you, even though I have good 3rd party straps. At some points it's not about the comfort of carrying them, its about the weight. I rarely take even my DA*60-250 these days. I prefer lighter.
And on a 15 km hike, (10 miles approx.) even a DA*60-250 will cause considerable discomfort with lots of shifting the bag from shoulder to shoulder etc. Sometimes it's a matter of comfort. Sometimes it's honestly a matter of too much weight. Especially with larger lenses, too much weight is a real thing.